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Calcium D-Glucarate

What is Calcium D-Glucarate?

Also known as D-Glucarate, D-Glucaric Acid, or Glucaric Acid Calcium D-Glucarate is the calcium salt of D-glucaric acid. D-glucaric acid is a natural substance that is found in many fruits and vegetables.

Calcium D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. One of the key ways in which the body eliminates toxic chemicals as well as hormones such as oestrogen is by attaching glucuronic acid to them in the liver and then excreting this complex in the bile.

Beta-glucuronidase is a bacterial enzyme that breaks the bond between the excreted compound and glucuronic acid. When beta-glucuronidase breaks the bond, the hormone or toxic chemical that is released is available to be reabsorbed into the body instead of being excreted.

An elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers like breast, prostate, and colon cancers. This is the main reason that Calcium D-Glucarate in used in supplements that concern Cancer.

Side Effects and Warnings of Calcium D-Glucarate

No side effects have been reported with calcium D-glucarate. Although there are no known drug interactions, many drugs (especially hormones) are metabolized in the liver by binding to glucuronic acid. It is therefore possible that taking calcium D-glucarate could increase the elimination of certain drugs or hormones from the body, thereby reducing their effectiveness.

You should always seek medical advice before you use Calcium D-glucarate or any other diet supplement to avoid any possible issues.

 

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