Glutamine

What is Glutamine?

Glutamine is synthesized from glutamate and ammonia, and is the main fuel that the intestinal cells need for maintenance and repair.

Since glutamine is produced by the human body, supplementation is not essential in order to survive. However, supplementation with Glutamine is often claimed to be beneficial for the following uses:
 

• Depression and anxiety
• Insomnia, moodiness, and irritability
• Attention deficit hyperactivity disorder (ADHD)
• Crohn's disease
• Diarrhoea
• Ulcerative colitis
• Excessive weight loss due to HIV or AIDS
• Sickle cell anaemia among other conditions
  

Glutamine is synthesized in both skeletal muscle and in adipose tissue in addition to the lungs, liver and brain. As such, it has received some interest for addressing chemotherapy. Glutamine is directly involved in the regulation of protein synthesis and breakdown and is a powerful anabolic stimulus.

Glutamine is a supplement that is used in weightlifting, bodybuilding, endurance and other sports, as well as by those who suffer from muscular cramps or pain particularly for elderly people.

Glutamine is an amino acid that promotes improved immune system and brain function, balanced blood sugar levels, increased muscle mass, and digestive tract health, and is also crucial in nitrogen metabolism

Side Effects and Warnings of Glutamine

In general, studies have reported no significant side effects with glutamine supplementation. There has been one case of high liver enzymes probably related to IV glutamine supplementation, and it has been reported that glutamine supplementation may cause mania in people with bipolar disorder.

There is also concern that high doses of glutamine could cause effects in the brain (such as psychological problems) due to a build up of glutamate and ammonia, since the body can break down glutamine into ammonia and glutamate. In theory, glutamine may also increase the risk of seizures.

There is still more research to be done on the possible side effects of using Glutamine. This is the main reason you should always seek medical advice before starting this or any other dietary supplement.

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